Soluble CD146 and disease
نویسندگان
چکیده
منابع مشابه
CD146 and its soluble form regulate monocyte transendothelial migration.
OBJECTIVES During inflammation, cell adhesion molecules are modulated or redistributed for leukocyte transmigration. Among molecules at the interendothelial junction, CD146 is involved in cell-cell cohesion and permeability, but its role in monocyte transmigration is unknown. METHODS AND RESULTS TNF enhanced CD146 expression at the junction and apical membrane of human umbilical veins endothe...
متن کاملSoluble CD146 in cerebrospinal fluid of active multiple sclerosis.
The soluble form of CD146 has been reported to be present in various inflammatory diseases and displays pro-inflammatory properties. However, little is known about sCD146 in multiple sclerosis (MS). Here we show that sCD146 is significantly elevated in the cerebrospinal fluid of patients with active MS compared with that of inactive MS or patients with non-demyelinating diseases. Moreover, abno...
متن کاملSoluble CD146 is generated by ectodomain shedding of membrane CD146 in a calcium-induced, matrix metalloprotease-dependent process.
CD146 is a cell adhesion molecule localized at the endothelial junction and is involved in the control of cell-cell cohesion. In this study, we showed that calcium influx in human microvascular lung endothelial cells results in the loss of surface CD146 and the release of soluble CD146. This calcium-induced CD146 shedding could be prevented with inhibitors of matrix metalloproteases indicating ...
متن کاملEndothelial biomarker soluble CD146 suggests that angiogenesis plays an important role in progression of fibrosis in liver disease
CD146, an element of the endothelial junctionhas been evaluated in several pathological conditions with altered endothelial function but never before in patients with liver disease. As angiogenesis and inflammation were implicated in the development of liver fibrosis, we have explored this suggestion by evaluating levels of sCD146 in a group of patients with chronic liver diseases (CLD) and in ...
متن کاملSoluble CD146, an innovative and non-invasive biomarker of embryo selection for in vitro fertilization
Although progress was made in in vitro fertilization (IVF) techniques, the majority of embryos transferred fail to implant. Morphology embryo scoring is the standard procedure for most of IVF centres for choosing the best embryo, but remains limited since even the embryos classified as "top quality" may not implant. As it has been shown that i) CD146 is involved in embryo implantation and ii) m...
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ژورنال
عنوان ژورنال: SCIENTIA SINICA Vitae
سال: 2018
ISSN: 1674-7232
DOI: 10.1360/n052018-00178